Figure 3: The lag-phase depends on the leak rate.
From: The lag-phase during diauxic growth is a trade-off between fast adaptation and high growth rate

(a) Three example simulations illustrating the lag-phase for leak2 = 0.1, 0.01, 0.001; the remaining parameters were fixed; see Supplementary Information for parameter values used. Here we used N1 = 80000 and N2 = 600000. (b) Distribution of the number of permeases in the population during the lag-phase for the simulation with the smallest leak rate in (a). We consider times t = 120, 150, 180 and only cells with at least one permease. Over time there is an increasing number of cells with more than one P2 permease. (c) Fraction of cells without a single P2 in a population after 100 time units. Each histogram represents 10000 simulation with a given saturation level of the permeases K; see main text for details. At low saturation levels (K = 333) the secondary metabolism is switched off and none of the cells expresses P2. Increasing the saturation point leads to bistable behaviour where the secondary metabolism is switched on sometimes only and then to all cells expressing P2.