Figure 1

Intragastric administration of GW9508 ameliorates high cholesterol diet (HCD) - induced hepatic lipid accumulation in C57BL/6 mice.

C57BL/6 mice were fed the 0.2% cholesterol diet for 3 days by gavage daily with either vehicle or GW9508 (100 mg/kg BW/day). After a 4 h fast, mice were sacrificed. Livers were collected from mice fed a control diet, a HCD supplemented with vehicle and a HCD supplemented with GW9508. (A) LXRα and LXRβ expression was detected by western blot, data are presented as the mean ± SEM, *p < 0.05, versus control diet-fed mice. (B) Representative oil red O staining of liver cryosections, bar = 25 μm. (C) Hepatic lipid contents, data are presented as the mean ± SEM from 6–7 animals of each group. **p < 0.01, ***p < 0.001, versus control diet-fed mice; ^#p < 0.05, ^###p < 0.001, versus HCD-fed plus vehicle mice.