Figure 2
Administration of GW9508 suppresses LXR activation-induced upregulation of hepatic lipogenic gene expression and activates AMPK-ACC signal pathway in C57BL/6 mice.
Western blot analysis of protein expression and corresponding densitometric quantification of FAS, SCD1, ACC, MTP, PPARα (A) and phosphorylation of AMPKα (Thr172) and ACC (Ser79) (B) were performed. The data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, versus control diet-fed mice; #p < 0.05, ##p < 0.01, versus HCD-fed plus vehicle mice.
