Table 2 Demographic profile and clinical features of culture-confirmed TBM patients with and without phenotypic drug resistance.
From: High rate of drug resistance among tuberculous meningitis cases in Shaanxi province, China
Variable | Drug resistanta = 12 (%) | Drug susceptible N = 13 (%) | Total N = 25 (%) |
|---|---|---|---|
Median age; years (range) | 26 (3–65) | 27 (3–82) | 26 (3–82) |
Female | 8 (66.7) | 9 (69.2) | 17 (68.0) |
History | |||
Fever | 9 (75.0) | 10 (76.9) | 19 (76.0) |
Headache | 9 (75.0) | 11 (84.6) | 20 (80.0) |
Vomiting | 2 (16.7) | 5 (38.5) | 7 (28.0) |
Seizures | 2 (16.7) | 2 (15.4) | 4 (16.0) |
Previous TB treatment | 4 (33.3) | 4 (30.8) | 8 (32.0) |
MRC grading b | |||
Grade 1 | 2 (16.7) | 2 (15.4) | 4 (16.0) |
Grade 2a | 2 (16.7) | 1 (7.7) | 3 (12.0) |
Grade 2b | 6 (50.0) | 6 (46.2) | 12 (48.0) |
Grade 3 | 2 (16.7) | 4 (30.8) | 6 (24.0) |
Imaging | |||
Chest X-ray suggestive of TB | 10 (83.3) | 9 (69.2) | 19 (76.0) |
Hydrocephalus | 5 (41.7) | 6 (46.2) | 11 (44.0) |
Basal meningeal enhancement | 4 (33.3) | 5 (38.5) | 9 (36.0) |
Infarcts | 2 (16.7) | 4 (30.8) | 6 (24.0) |
CSF findings | |||
Total leukocyte count cells/μl; median (range) | 225 (27–683) | 101 (7–319) | 143 (7–683) |
Lymphocytes >50% | 6 (50.0) | 8 (61.5) | 14 (56.0) |
Protein mg/dl; median(range) | 1.3 (0.2–3.9) | 1.6 (0.9–3.8) | 1.4 (0.2–3.9) |
Protein >1.0 mg/dl | 7 (58.3) | 10 (76.9) | 17 (68.0) |
Glucose mmol/l; median(range) | 1.5 (0.4–3.6) | 1.6 (0.6–3.8) | 1.5 (0.4–3.8) |
Glucose <2.2 mmol/l | 10 (83.3) | 12 (92.3) | 22 (88.0) |
Death before hospital discharge | 2 (16.7) | 3 (23.1) | 5 (20.0) |
