Table 7 Detection of mutations conferring KAN resistance by DNA sequencing in MTB isolates.

From: Rapid diagnosis of MDR and XDR tuberculosis with the MeltPro TB assay in China

Locus

Mutation type

No. of isolates (%)

Shandong

Guangdong

Total

rrs

A1401G

20(74.1)

19(40.4)

39(52.7)

C1402T

0(0.0)

2(4.3)

2(2.7)

G1484T

0(0.0)

1(2.1)

1(1.4)

eis

āˆ’10Gā†’ā†’A

2(7.4)

2(4.3)

4(5.4)

āˆ’12Cā†’ā†’T

0(0.0)

1(2.1)

1(1.4)

āˆ’14Gā†’ā†’T

0(0.0)

1(2.1)

1(1.4)

None

5(18.5)

21(44.7)

26(35.1)

Total

27(100.0)

47(100.0)

74(100.0)

  1. aStatistical analysis is performed to compare the proportion of KAN-resistant isolates harboring genetic mutation between Shandong and Guangdong (Ļ‡2ā€‰=ā€‰5.13, Pā€‰=ā€‰0.023).
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