Table 1 The main information for 85 CRC susceptibility variants.

From: Colorectal cancer risk genes are functionally enriched in regulatory pathways

SNP	Pubmed ID	Disease/Trait	Gene	P value	OR or beta	95% CI
rs4939827	18372901	CRC	SMAD7	8.00E-28	1.2	[1.16–1.24]
rs7014346	18372901	CRC	LOC101930033	9.00E-26	1.19	[1.15–1.23]
rs174537	24836286	CRC	MYRF	9.00E-21	1.16	[1.12–1.19]
rs16892766	18372905	CRC	LINC00536-EIF3H	3.00E-18	1.27	[1.20–1.34]
rs10795668	24836286	CRC	RNA5SP299-LINC00709	5.00E-15	1.15	[1.11–1.19]
rs6983267	17618284	CRC	CCAT2, LOC101930033	1.00E-14	1.27	[1.16–1.39]
rs647161	24836286	CRC	C5orf66	2.00E-14	1.15	[1.11–1.19]
rs6983267	24836286	CRC	CCAT2, LOC101930033	5.00E-14	1.14	[1.10–1.18]
rs10795668	18372905	CRC	RNA5SP299-LINC00709	3.00E-13	1.12	[1.10–1.16]
rs10505477	24737748	CRC	LOC101930033	8.00E-13	1.2	[NR]
rs4939827	17934461	CRC	SMAD7	1.00E-12	1.16	[1.09–1.27]
rs11196172	24836286	CRC	TCF7L2	1.00E-12	1.14	[1.10–1.18]
rs2423279	24836286	CRC	SRSF10P2	3.00E-12	1.13	[1.09–1.17]
rs73376930	24737748	CRC	GREM1, LOC100131315	1.00E-11	1.25	[NR]
rs6983267	23266556	CRC	CCAT2, LOC101930033	1.00E-11	1.13	[1.09–1.18]
rs10505477	17618283	CRC	LOC101930033	3.00E-11	1.17	[1.12–1.23]
rs7229639	24448986	CRC	SMAD7	3.00E-11	1.22	[1.15–1.29]
rs2427308	24737748	CRC	CABLES2	3.00E-11	1.24	[NR]
rs1035209	24737748	CRC	NKX2-3-SLC25A28	5.00E-11	1.12	[1.08–1.16]
rs6983267	18372905	CRC	CCAT2, LOC101930033	7.00E-11	1.24	[1.17–1.33]
rs11255841	24737748	CRC	RNA5SP299-LINC00709	7.00E-11	1.19	[NR]
rs1321311	22634755	CRC	N/A	1.00E-10	1.1	[1.07–1.13]
rs10774214	24836286	CRC	RPL18P9-CCND2	1.00E-10	1.14	[1.09–1.18]
rs647161	23263487	CRC	C5orf66	1.00E-10	1.11	[1.08–1.15]
rs961253	19011631	CRC	FGFR3P3-CASC20	2.00E-10	1.12	[1.08–1.16]
rs11169552	20972440	CRC	DIP2B-ATF1	2.00E-10	1.09	[1.05–1.11]
rs4925386	20972440	CRC	LAMA5	2.00E-10	1.08	[1.05–1.10]
rs4939827	23266556	CRC	SMAD7	2.00E-10	1.12	[1.09–1.16]
rs3824999	22634755	CRC	POLD3	4.00E-10	1.08	[1.05–1.10]
rs647161	23263487	CRC	C5orf66	4.00E-10	1.17	[1.11–1.22]
rs10774214	23263487	CRC	RPL18P9-CCND2	5.00E-10	1.17	[1.11–1.23]
rs3802842	18372901	CRC	COLCA2, COLCA1	6.00E-10	1.11	[1.08–1.15]
rs10849432	24836286	CRC	LOC102723767	6.00E-10	1.14	[1.09–1.18]
rs5934683	22634755	CRC	GPR143-SHROOM2	7.00E-10	1.07	[1.04–1.10]
rs4444235	19011631	CRC	RPS3AP46-MIR5580	8.00E-10	1.11	[1.08–1.15]
rs6691170	20972440	CRC	DUSP10-QRSL1P2	1.00E-09	1.06	[1.03–1.09]
rs12241008	25105248	CRC	VTI1A	1.00E-09	1.13	[1.09–1.18]
rs6687758	20972440	CRC	DUSP10-QRSL1P2	2.00E-09	1.09	[1.06–1.12]
rs10411210	19011631	CRC	RHPN2	5.00E-09	1.15	[1.10–1.20]
rs2423279	23263487	CRC	SRSF10P2	7.00E-09	1.1	[1.06–1.14]
rs35509282	25023989	CRC	MTHFD2P4-TOMM22P4	8.00E-09	1.53	[1.39–1.67]
rs7758229	21242260	CRC	SLC22A3	8.00E-09	1.28	[1.18–1.39]
rs6687758	24836286	CRC	DUSP10-QRSL1P2	9.00E-09	1.12	[1.08–1.17]
rs4143094	24743840	CRC^b	GATA3	9.00E-09	1.17	[1.11–1.23]
rs9929218	19011631	CRC	CDH1	1.00E-08	1.1	[1.06–1.12]
rs1800469	24836286	CRC	TGFB1, B9D2	1.00E-08	1.09	[1.06–1.12]
rs4779584	21761138	CRC	SCG5-GREM1	2.00E-08	1.18	[1.11–1.24]
rs704017	24836286	CRC	ZMIZ1-AS1	2.00E-08	1.1	[1.06–1.13]
rs7229639	24836286	CRC	SMAD7	2.00E-08	1.2	[1.16–1.25]
rs140355816	24737748	CRC	LINC00536-EIF3H	2.00E-08	1.59	[NR]
rs6983267	21242260	CRC	CCAT2, LOC101930033	2.00E-08	1.18	[1.11–1.25]
rs10936599	20972440	CRC	MYNN	3.00E-08	1.04	[1.04–1.10]
rs12603526	24836286	CRC	NXN	3.00E-08	1.1	[1.06–1.14]
rs10774214	23263487	CRC	RPL18P9-CCND2	3.00E-08	1.09	[1.06–1.13]
rs34245511	24737748	CRC	LIMA1	3.00E-08	1.14	[NR]
rs367615	23300701	CRC	KRT18P42-MAN2A1	4.00E-08	1.35	[1.20–1.49]
rs11903757	23266556	CRC	NABP1-SDPR	4.00E-08	1.16	[1.10–1.22]
rs6469656	24836286	CRC	LINC00536-EIF3H	5.00E-08	1.09	[1.06–1.13]
rs3217810	23266556	CRC	CCND2	6.00E-08	1.2	[1.12–1.28]
rs4948317	24836286	CRC	BICC1	7.00E-08	1.1	[1.06–1.13]
rs13343954	24737748	CRC	RHPN2	7.00E-08	1.18	[NR]
rs10911251	23266556	CRC	LAMC1	9.00E-08	1.09	[1.06–1.13]
rs4939827	21761138	CRC	SMAD7	1.00E-07	1.14	[1.08–1.18]
rs2423279	23263487	CRC	SRSF10P2	2.00E-07	1.14	[1.08–1.19]
rs3802842	24836286	CRC	COLCA2, COLCA1	3.00E-07	1.09	[1.05–1.12]
rs3217901	23266556	CRC	CCND2	3.00E-07	1.1	[1.06–1.14]
rs13130787	23266556	CRC	ATOH1-HMGB3P15	3.00E-07	1.09	[1.06–1.13]
rs16892766	21761138	CRC	LINC00536-EIF3H	4.00E-07	1.24	[1.14–1.34]
rs3802842	21761138	CRC	COLCA2, COLCA1	4.00E-07	1.14	[1.08–1.20]
rs3802842	23266556	CRC	COLCA2, COLCA1	4.00E-07	1.11	[1.06–1.15]
rs59336	23266556	CRC	TBX3	4.00E-07	1.09	[1.06–1.13]
rs4779584	18372905	CRC	SCG5-GREM1	5.00E-07	1.23	[1.14–1.34]
rs4779584	23266556	CRC	SCG5-GREM1	5.00E-07	1.12	[1.08–1.19]
rs12412391	24836286	CRC	LOC101927324, LINC01475	7.00E-07	1.08	[1.05–1.11]
rs1028166	25192705	CRC^a	N/A	7.00E-07	1.49	[1.27–1.74]
rs2901879	24743840	CRC^b	MEIS1-AS2-DNMT3AP1	7.00E-07	1.11	[1.06–1.16]
rs1871438	24743840	CRC^b	NPM1P5-ST8SIA2	8.00E-07	1.11	[1.07–1.16]
rs1665650	23263487	CRC	HSPA12A	9.00E-07	1.13	[1.08–1.19]
rs4849303	24743840	CRC^b	ACOXL	1.00E-06	1.12	[1.08–1.18]
rs4147045	24743840	CRC^b	KRT18P63-RPL21P46	1.00E-06	1.2	[1.11–1.3]
rs8180040	23350875	CRC	KLHL18-PTPN23	2.00E-06	1.28	[1.15–1.41]
rs4939827	18372905	CRC	SMAD7	2.00E-06	1.18	[1.10–1.25]
rs39453	23300701	CRC	SNRPCP19-CYCS	2.00E-06	1.28	[1.16–1.43]
rs6855885	25192705	CRC^a	CCSER1	2.00E-06	1.11	[1.06–1.16]
rs1933755	25192705	CRC^a	TMEM200A-SMLR1	2.00E-06	1.19	[1.11–1.28]
rs1370916	24743840	CRC^b	MRPL42P4-TNS3	2.00E-06	1.11	[1.06–1.15]
rs6989010	24743840	CRC^b	LINC00681-KIAA1456	2.00E-06	1.64	[1.33–2]
rs2593957	24743840	CRC^b	MORC1	2.00E-06	1.15	[1.09–1.2]
rs12534701	24743840	CRC^b	DPP6	2.00E-06	1.17	[1.09–1.24]
rs4855695	24743840	CRC^b	MORC1-FLJ22763	2.00E-06	1.14	[1.08–1.20]
rs12548021	23350875	CRC	DUSP4-RPL17P33	3.00E-06	1.28	[1.155–1.42]
rs12309274	24836286	CRC	WNK1	3.00E-06	1.11	[1.06–1.16]
rs10411210	24836286	CRC	RHPN2	3.00E-06	1.12	[1.07–1.17]
rs17730929	23300701	CRC	RPS23P3-CENPC	3.00E-06	1.47	[1.25–1.72]
rs10114408	23300701	CRC	MIR4291-BARX1	3.00E-06	1.37	[1.20–1.56]
rs4591517	23300701	CRC	SALL4P5-RPL24P7	3.00E-06	1.06	[0.88–1.29]
rs10879357	23300701	CRC	TPH2	3.00E-06	1.25	[1.14–1.39]
rs57046232	24737748	CRC	FGFR3P3-CASC20	3.00E-06	1.11	[NR]
rs2057314	23266556	CRC	DCBLD1	3.00E-06	1.08	[1.04–1.11]
rs17094983	23266556	CRC	DACT1-RPL31P4	3.00E-06	1.13	[1.08–1.20]
rs7999699	24743840	CRC^b	RPL27AP8-SUCLA2	3.00E-06	1.32	[1.18–1.47]
rs3104964	23350875	CRC	LOC100616530, C8orf37-AS1	4.00E-06	1.27	[1.14–1.40]
rs9365723	23300701	CRC	SYNJ2	4.00E-06	1.27	[1.15–1.41]
rs11671104	24743840	CRC^b	GOLGA2P9-ZNF492	4.00E-06	1.25	[1.13–1.37]
rs10752881	24836286	CRC	KRT18P28-LAMC1	5.00E-06	1.07	[1.04–1.10]
rs7248888	24743840	CRC^b	PNMAL1	5.00E-06	1.37	[1.19–1.56]
rs7315438	21761138	CRC	TBX3-UBA52P7	6.00E-06	1.11	[1.06–1.15]
rs4813802	23266556	CRC	CASC20-BMP2	7.00E-06	1.1	[1.05–1.14]
rs2128382	23266556	CRC	GSDMC-FAM49B	8.00E-06	1.11	[1.06–1.16]
rs1912453	23266556	CRC	C1orf110	9.00E-06	1.07	[1.04–1.11]

CRC, colorectal cancer; CRC^a, CRC (calcium intake interaction); CRC^b, CRC (diet interaction); OR, odds ratio; CI, confidence interval; Chr, Chromosome; NR, not reported.

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Table 1 The main information for 85 CRC susceptibility variants.

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