Table 2 Significant GO pathways from pathway analysis of 128 CRC susceptibility genes.

From: Colorectal cancer risk genes are functionally enriched in regulatory pathways

GO categories

ID

Name

C

O

E

R

rawP

adjP

biological process

GO:0010717

regulation of epithelial to mesenchymal transition

38

5

0.17

28.73

7.73E-07

8.55E-05

biological process

GO:0060675

ureteric bud morphogenesis

68

6

0.31

19.27

6.43E-07

8.55E-05

biological process

GO:0030178

negative regulation of Wnt receptor signaling pathway

112

7

0.51

13.65

7.60E-07

8.55E-05

biological process

GO:0035295

tube development

436

12

2

6.01

5.73E-07

8.55E-05

biological process

GO:0060389

pathway-restricted SMAD protein phosphorylation

37

5

0.17

29.51

6.74E-07

8.55E-05

biological process

GO:0001657

ureteric bud development

104

7

0.48

14.7

4.59E-07

8.55E-05

biological process

GO:0060393

regulation of pathway-restricted SMAD protein phosphorylation

33

5

0.15

33.08

3.72E-07

8.55E-05

biological process

GO:0046824

positive regulation of nucleocytoplasmic transport

73

6

0.33

17.95

9.82E-07

9.50E-05

biological process

GO:0048468

cell development

1461

21

6.69

3.14

1.20E-06

1.00E-04

biological process

GO:0048634

regulation of muscle organ development

104

6

0.48

12.6

7.84E-06

2.00E-04

biological process

GO:0090316

positive regulation of intracellular protein transport

88

6

0.4

14.89

2.96E-06

2.00E-04

biological process

GO:0032989

cellular component morphogenesis

1000

16

4.58

3.49

8.23E-06

2.00E-04

biological process

GO:0048729

tissue morphogenesis

472

11

2.16

5.09

8.81E-06

2.00E-04

biological process

GO:0048869

cellular developmental process

2829

29

12.96

2.24

6.09E-06

2.00E-04

biological process

GO:0051222

positive regulation of protein transport

163

7

0.75

9.38

9.29E-06

2.00E-04

biological process

GO:0001658

branching involved in ureteric bud morphogenesis

64

5

0.29

17.06

1.07E-05

2.00E-04

biological process

GO:0061138

morphogenesis of a branching epithelium

169

7

0.77

9.04

1.18E-05

2.00E-04

biological process

GO:0009887

organ morphogenesis

802

15

3.67

4.08

2.53E-06

2.00E-04

biological process

GO:0090092

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

168

7

0.77

9.1

1.13E-05

2.00E-04

biological process

GO:0045598

regulation of fat cell differentiation

64

5

0.29

17.06

1.07E-05

2.00E-04

biological process

GO:0016202

regulation of striated muscle tissue development

102

6

0.47

12.84

7.01E-06

2.00E-04

biological process

GO:0060485

mesenchyme development

162

7

0.74

9.44

8.93E-06

2.00E-04

biological process

GO:0042476

odontogenesis

103

6

0.47

12.72

7.41E-06

2.00E-04

biological process

GO:0035239

tube morphogenesis

300

9

1.37

6.55

8.57E-06

2.00E-04

biological process

GO:0022612

gland morphogenesis

110

6

0.5

11.91

1.08E-05

2.00E-04

biological process

GO:0048732

gland development

277

9

1.27

7.09

4.49E-06

2.00E-04

biological process

GO:0048762

mesenchymal cell differentiation

141

7

0.65

10.84

3.57E-06

2.00E-04

biological process

GO:0032388

positive regulation of intracellular transport

95

6

0.44

13.79

4.64E-06

2.00E-04

biological process

GO:0002009

morphogenesis of an epithelium

370

10

1.69

5.9

6.51E-06

2.00E-04

biological process

GO:2000027

regulation of organ morphogenesis

147

7

0.67

10.4

4.71E-06

2.00E-04

biological process

GO:0034330

cell junction organization

195

8

0.89

8.96

2.87E-06

2.00E-04

biological process

GO:0051153

regulation of striated muscle cell differentiation

64

5

0.29

17.06

1.07E-05

2.00E-04

biological process

GO:0042307

positive regulation of protein import into nucleus

61

5

0.28

17.9

8.45E-06

2.00E-04

biological process

GO:0045662

negative regulation of myoblast differentiation

10

3

0.05

65.51

1.08E-05

2.00E-04

biological process

GO:0001763

morphogenesis of a branching structure

196

8

0.9

8.91

2.98E-06

2.00E-04

biological process

GO:0000902

cell morphogenesis

945

16

4.33

3.7

4.00E-06

2.00E-04

biological process

GO:0048646

anatomical structure formation involved in morphogenesis

1594

21

7.3

2.88

4.88E-06

2.00E-04

biological process

GO:0000904

cell morphogenesis involved in differentiation

704

13

3.22

4.03

1.52E-05

3.00E-04

biological process

GO:0060284

regulation of cell development

495

11

2.27

4.85

1.38E-05

3.00E-04

biological process

GO:1901213

regulation of transcription from RNA polymerase II promoter involved in heart development

12

3

0.05

54.59

1.96E-05

3.00E-04

molecular function

GO:0008013

beta-catenin binding

63

5

0.28

18.1

8.03E-06

6.00E-04

cellular component

GO:0005913

cell-cell adherens junction

46

4

0.19

21.18

3.73E-05

3.30E-03

cellular component

GO:0070161

anchoring junction

218

6

0.89

6.7

3.00E-04

8.80E-03

cellular component

GO:0005912

adherens junction

201

6

0.83

7.27

2.00E-04

8.80E-03

  1. C, the number of reference genes in the category; O, the number of genes in the gene set and also in the category; E, expected number in the category; R, the ratio of enrichment, rawP, the p value from hypergeometric test; adjP, the p value adjusted by the multiple test adjustment.
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