Figure 1
From: PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers
Scatter plots of parasite responses to calcium channel (a) and sodium (b) blockers against dihydroartemisinin (DHA). Half maximal inhibitory concentrations (IC50) from each of 61 field Plasmodium falciparum isolates were plotted. Each color represents a compound as indicated: CIN, cinacalcet (correlation coefficient R = 0.765); PER, perhexiline (R = 0.618); LER, lercanidipine (R = 0.598); NIG, niguldipine (R = 0.568); NIS, nisoldipine (R = 0.757); AMI, amiodarone (R = 0.674); APR, aprindine hydrochloride (R = 0.595); QUI, quinidine (R = 0.602); TOC, tocainide (R = −0.595); and AMIL, amiloride (R = 0.738). These analyses were based on raw data in our previously study28.
