Figure 2
From: PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers
Isobolograms showing interactions of dihydroartemisinin (DHA) and selected calcium and sodium channel blockers for Plasmodium falciparum Dd2 and HB3 strains.
(a,b) lercanidipine; (c,d) niguldipine; (e,f) cinacalcet; (g,h) perhexiline; (i,j) lidocaine. FIC, fractional inhibitory concentration. Ratios of 1.0:0 (DHA:blocker), 0.9:0.1, 0.8:0.2, 0.7:0.3, 0.6:0.4, 0.5:0.5, 0.4:0.6, 0.3:0.7, 0.2:0.8, 0.1:0.9 and 0:1.0 were used, where 1.0 equals 4–16 fold of the half maximal inhibitory concentration (IC50) of each compound. ΣFIC values are listed in Supplementary Table 8.
