Figure 3

Plots of half maximal inhibitory concentration (IC₅₀) of progeny and parents of the Dd2 × HB3 cross and scores of logarithm (base 10) of odds (LOD) in response to lidocaine.

(a) IC₅₀ values and standard deviations from three independent tests. Dd2 and HB3 are the parents and the rest are progeny. C1^GC03, C2^GC03, C4^Dd2 and C6^7G8 are pfcrt allelic replaced parasites. C1^GC03 and C2^GC03 had wild type pfcrt (allelic exchange control parasites); C4^Dd2, Dd2 pfcrt allele; C6^7G8, 7G8 pfcrt allele. Shown for IC₅₀ assays are the Mean ± SEM, conducted in at least three independent experiments, see Supplementary Table 5 for values. (b) Plot of LOD scores of parasite response to lidocaine analyzed using microsatellite markers described previously³⁸. Qtl analysis was as described in the Methods section. t-test, *P < 0.05; **P < 0.01.