Figure 5
From: PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers
Responses of pfmdr1 allelic exchanged parasites to various artemether (ATM) and channel blocker combinations (Mean ΣFIC ± SD).
(a) ΣFIC of pfmdr1 allelic exchanged GCO3 parasites in response to ATM + nicardipine. (b) ΣFIC of pfmdr1 allelic exchanged GCO3 parasites in response to ATM + cinacalcet. (c) ΣFIC of pfmdr1 allelic exchanged GCO3 parasites in response to ATM + propafenone. (d) Representative isobologram results for ATM + propafenone; circles, GCO3 (SDD PfMDR1); boxes, GCO3SND (wild type PfMDR1 allele); *P < 0.05 (t-test, with at least three independent experiments).
