Figure 6
From: PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers
Responses of pfcrt and pfmdr1 allelic exchanged parasites to Artemether (ATM) and lumefantrine (LUM) combination (Mean ΣFIC ± SD).
(a) ΣFIC of pfcrt allelic exchanged GCO3 parasites in response to ATM + LUM combinations. (b) ΣFIC of pfmdr1 allelic exchanged GCO3 parasites in response to ATM + LUM combinations. Shown are the ΣFIC values ± SD of at least three independent experiments, see Supplementary Table 7 for values. Note GCO3SND was only significantly different from GCO3, but not the GCO3SDD allelic control parasite having the same SDD PfMDR1 allele due to large variations in repeats, indicating that transgenic modification of the lines was confounding the phenotype, precluding a clear conclusion about these comparisons. t-test, *P < 0.05; **P < 0.01.
