Table 1 Compounds highly correlated with dihydroartemisinin (DHA) in responses among 61 field isolates.

From: PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers

Name

R-value

P-value

Name

R-value

P-value

artenimol (DHA)$

0.8393

3.53E-16

imazalil sulphate*,$

0.7546

7.86E-12

dipyridamole*,$

0.8241

1.08E-15

gluconic acid, barium salt

0.7535

2.08E-11

podofilox$

0.8135

4.89E-15

sulconazole nitrate

0.7521

6.58E-12

glutathione$

0.8093

1.50E-14

tolterodina$

0.7520

6.65E-12

ergotamine d-tartrate#,$

0.8091

8.97E-15

pronethalol$

0.7515

2.51E-11

tert-butylhydroquinone

0.8059

1.15E-13

distamycin a$

0.7498

8.27E-12

econazole nitrate*,$

0.8059

1.37E-14

propafenone$

0.7483

9.58E-12

(s)-timolol$

0.8057

1.40E-14

verteporfin#

0.7443

1.12E-10

triclosan*,$

0.8038

3.05E-14

benzyl alcohol

0.7422

3.91E-11

oxiconazole nitrate$

0.8033

1.94E-14

17-allylamino-geldanamycin$

0.7419

2.68E-11

chlorobutanol$

0.7982

3.72E-14

bifonazole*

0.7401

3.19E-11

benperidol#,$

0.7940

6.25E-14

amiloride$

0.7384

1.24E-10

toxaphene$

0.7916

8.42E-14

dihydroergocristine#,$

0.7311

4.88E-11

bromocriptine#,$

0.7916

8.44E-14

rifampin#,$

0.7225

1.04E-10

artemisininum (ART)

0.7880

1.30E-13

vitamin k2

0.7213

1.69E-10

tegaserod$

0.7832

3.70E-13

miconazole#

0.7208

1.21E-10

rifapentine#,$

0.7780

6.72E-13

lumefantrine#,$

0.7182

2.20E-10

levamisole hydrochloride$

0.7702

1.58E-12

clotrimazole#,$

0.7173

2.37E-10

mefloquine hydrochloride#

0.7700

2.54E-12

tolperisone hydrochloride

0.7165

3.37E-09

anthraquinone$

0.7682

1.89E-11

carminomycin

0.7142

2.13E-10

artemetero (artemether)$

0.7663

1.52E-12

fluticasone propionate$

0.7116

2.34E-09

cefsulodin sodium salt$

0.7660

1.57E-12

zeaxanthin#

0.7090

5.81E-09

tioconazole*,$

0.7659

1.59E-12

pirarubicin$

0.7089

3.33E-10

cinacalcet hydrochloride#,$

0.7654

2.62E-12

aa-861$

0.7041

4.92E-10

halofantrine hydrochloride#

0.7637

3.11E-12

meclozine dihydrochloride

0.7016

1.38E-08

clorophene$

0.7587

1.94E-11

sulisobenzone

0.7005

2.62E-09

dextroamphetamine saccharate#,$

0.7563

4.31E-12

   
  1. Name, compound names; R-value, values of Pearson correlation coefficient. The R values were calculated using the log10IC50 values. The P-values were calculated using the exact bivariate normal distribution.
  2. *Associated with pfmdr1 at P = <5.7E-5.
  3. #Linked to pfmd1 in crosses and confirmed by allelic exchanged parasites.
  4. $Associated with pfcrt at p < 6.03E-05 and FRD < 5.0E-03.
  5. These results were compiled and analyzed based on data in our previous screening29.
Back to article page