Figure 2
From: Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design
Tissue Physiology versus Molecular Weight: the optimal molecular weight probes for different tissues.
The values are based on 50% extraction fraction using the vessel type, blood flow and vessel surface area (A). Tumors have elevated macromolecular permeability, but the elevated interstitial pressure may contribute to lower effective permeability than fenestrated tissue for low molecular weight compounds. The data and fit for tumor values are identical to ref. 4 (B). The 50% extraction fraction is an arbitrary cutoff based on diminishing returns as seen for the tumor (C).
