Figure 5 | Scientific Reports

Figure 5

From: Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia

Figure 5

LDE225 alone or in combination with nilotinib significantly reduces LTC-IC numbers in primary CD34+ CP-CML samples.

LTC-IC from (A) CD34+ CP-CML cells (n = 5) and (B) normal CD34+ haemopoietic cells (n = 3) were cultured in the presence of LDE225 10nM, nilotinib 5μM or both (combination). The results shown represent the mean ± SEM normalised to an untreated control. Significance values; *p < 0.05.

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