Table 4 Differences of clinical characteristics between patients with ACLF included in the current study and patients from the CANONIC study.
Characteristics | Chinese Patients N = 300 | CANONIC patients N = 417 | p-value |
|---|---|---|---|
Age (y) | 46.5 ± 11.3 | 55.8 ± 11.7 | <0.001 |
Male sex | 233(77.7) | 267(64.0) | <0.001 |
Previous decompensation | <0.001 | ||
No | 157(52.3) | 98(24.9) | |
Yes | 143(47.7) | 295(75.1) | |
Ascites | 229(76.6) | 324(78.5) | 0.7346 |
Mean arterial pressure(mmHg) | 84 ± 18 | 81 ± 13 | 0.0142 |
Cause of cirrhosis | |||
Alcohol,noHCV | – | 233(58.4) | – |
No Alcohol,HCV | – | 59(14.8) | – |
Alcohol+HCV | – | 37(9.3) | – |
Other Etiologies* | – | 70(17.5) | – |
HBV alone | 263(87.7) | – | – |
HBV+Alcohol | 19(6.3) | – | – |
HBV+other hepatitis virus | 12(4.0) | – | – |
HBV+schistosomiasis | 6(2.0) | – | – |
Organ failures | |||
Liver | 233(77.7) | 157(37.7) | <0.001 |
Kidney | 85(28.3) | 217(52.0) | <0.001 |
Cerebral | 71(23.7) | 94(22.5) | 0.7925 |
Coagulation | 203(67.7) | 118(28.3) | <0.001 |
Circulation | 57(19.0) | 78(18.7) | 0.9977 |
Lungs | 43(14.3) | 47(11.3) | 0.2684 |
Renal dysfunction | 44(14.7) | 64(15.4) | 0.801 |
Cerebral dysfunction | 54(18.0) | 130(31.3) | <0.001 |
Laboratory data | |||
Hematocrit(%) | 30 ± 8 | 28 ± 9 | 0.0018 |
Leucocytes(×109/L) | 10.3 ± 6.8 | 9.5 ± 6.0 | 0.1033 |
Platelet count(×109/L) | 85 ± 63 | 103 ± 70 | <0.001 |
Serum bilirubin(mg/dL) | 27 ± 16 | 11 ± 11 | <0.001 |
International normalized ratio | 3.2 ± 2.1 | 2.0 ± 0.8 | <0.001 |
Alanine aminotransferase(U/L) | 315 ± 589 | 69 ± 122 | <0.001 |
Aspartate aminotransferase(U/L) | 254 ± 451 | 202 ± 991 | 0.3454 |
γ-Glutamyltransferase(U/L) | 70 ± 98 | 154 ± 207 | <0.001 |
Serum creatinine(mg/dL) | 1.5 ± 1.5 | 2.0 ± 1.5 | <0.001 |
Serum sodium(mmol/L) | 130 ± 7 | 133.5 ± 7 | <0.001 |
Site of hospitalization | <0.001 | ||
Intensive care unit | 0(0.0) | 98(23.6) | |
Ward | 300(100.0) | 318(76.4) | |
ACLF grades: | <0.001 | ||
ACLF-I | 55(18.3) | 214(51.3) | |
ACLF-II | 147(49.0) | 147(35.3) | |
ACLF-III | 98(32.7) | 56(13.4) | |
Mortality | |||
28 days | 129(43.0) | 125(30.0) | <0.001 |
90 days | 151(50.3) | 178(42.7) | 0.0624 |
180 days | 154(51.3) | 204(48.9) | 0.6358 |
365 days | 156(52.0) | 228(54.7) | 0.4709 |
