Figure 1 | Scientific Reports

Figure 1

From: An early granulocyte colony-stimulating factor treatment attenuates neuropathic pain through activation of mu opioid receptors on the injured nerve

Figure 1

GCSF treatment alleviates mechanical allodynia in rats with CCI.

Statistically significant mechanical allodynia developed in the vehicle-treated CCI rats, compared to the sham-operated controls from the 1st to the 7th day after nerve injury (P < 0.01). In contrast, early GCSF treatment alleviated mechanical allodynia from the 1st to the 7th day after nerve injury compared to the vehicle-treated CCI rats (P < 0.01). The data are shown as the mean ± SEM. Two-way repeated measures ANOVA followed by post hoc LSD test. ##P < 0.01: vehicle-treated groups compared to sham-operated controls. **P < 0.01: GCSF-treated CCI groups compared to vehicle-treated CCI groups (n = 7, in each group).

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