Figure 5
GCSF decreased the p-p38/total p38 ratio in the spinal dorsal horn.
The phosphorylated-p38/total p38 ratio in the spinal dorsal horn, as determined by western blot analysis, was significantly higher in vehicle-treated CCI rats than in sham controls on the 3rd day after nerve injury (P < 0.01). In contrast, a significantly lower p-p38/total p38 ratio was observed in the dorsal horn of GCSF-treated CCI rats than in vehicle-treated CCI rats on the 3rd day after nerve injury (P < 0.01). The data are shown as the mean ± SEM. #P < 0.05, ##P < 0.01: vehicle-treated groups compared to sham-operated controls. *P < 0.05, **P < 0.01: GCSF-treated CCI groups compared to vehicle-treated CCI groups. One-way ANOVA, post hoc LSD test or Kruskal–Wallis, post hoc Mann–Whitney rank-sum test, if appropriate (n = 6, in each group).
