Figure 1: Truncated ESR1 amplifications in two metastatic endometrial carcinomas. | Scientific Reports

Figure 1: Truncated ESR1 amplifications in two metastatic endometrial carcinomas.

From: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth

Figure 1

Dot plots of ESR1 copy-numbers (y-axis) determined by GeneChip measurements (grey dots) of two metastatic endometrial carcinomas (above: #4, below #2) are shown on the left. Horizontal red lines indicate the segmented copy-number level of chromosomal positions (mega base pairs) on chromosome 6 (x-axis). Position of full length ESR1 (vertical green lines) as well as ESR1 exons 1-4 and 5-8 are indicated as green rectangles (see also Figure 2). Regarding FISH signals of ESR1 (green) and centromere 6 (orange) within a tumor nucleus (blue) are shown on the right. FISH and regarding GeneChip copy-number data of 28 metastatic endometrial carcinoma are summarized in Appendix A. FISH analyses of these tumors are documented in Supplementary Optical Dataset S1.

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