Figure 2: Truncated ESR1 amplifications in TCGA endometrial carcinomas. | Scientific Reports

Figure 2: Truncated ESR1 amplifications in TCGA endometrial carcinomas.

From: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth

Figure 2

Log2 ESR1 copy number ratios of eight uterine corpus endometrial carcinomas with ESR1 full-length amplification and eight carcinomas with ESR1 truncating copy-number alterations are shown in horizontal bars (increased: red, normal/neutral: white, decreased: blue) (A). The corresponding heatmap of exon expression is estimated from RNA-Seq data (normalized relative higher: red, neutral: white, lower: blue) (B). Corresponding ER protein domains according to PROSITE (PS) and Pfam (PF) databases (http://www.ebi.ac.uk/interpro/) are shown in panel C (see http://www.ensembl.orgfor ESR1 transcript variants). 

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