Figure 2

Normal lung development in Creb1^EpKO, Creb1^MesKO and Creb1^EndoKO mice.

(a–f) Haematoxylin and eosin-stained tissue sections from E18.5 Creb1^EpKO, Creb1^MesKO, Creb1^EndoKO and Creb1^fl−/− lungs. Loss of Creb1 separately in lung epithelium (b), mesenchyme (d) and endothelium (e) produces no phenotype compared to controls (a,c). Lungs of Creb1^fl−/− lungs mice exhibit a severe defect in sacculation, with little or no expansion of proximal and distal airways (f). All images are representative of at least three animals per genotype. Scale bar: 180 μm.