Figure 2: HPLC Analysis of PEG modified Fluorescent Polystyrene Nanoparticle Biodistribution Following I/R Injury. | Scientific Reports

Figure 2: HPLC Analysis of PEG modified Fluorescent Polystyrene Nanoparticle Biodistribution Following I/R Injury.

From: Distribution of Systemically Administered Nanoparticles Reveals a Size-Dependent Effect Immediately following Cardiac Ischaemia-Reperfusion Injury

Figure 2

(A) Increased retention of nanoparticles with core diameters of 20, 100, 200 and 500 nm (hydrodynamic diameters of 65, 136, 226 and 548 nm respectively) occurs in the heart following I/R injury. Larger nanoparticles show a greater degree of off target retention, particularly by the spleen. (B) Expressing nanoparticle retention by the heart in terms of fold change in I/R vs. sham mice shows a clear size dependent accumulation. Statistical annotations inside the base of each bar show comparisons between retention in I/R and sham operated mice. Error bars show the standard error of the mean. The number of animals per group is shown in (A) for the heart. * = P ≤ 0.05, ** = P ≤ 0.01, *** = P ≤ 0.001, **** = P ≤ 0.0001, ns = P > 0.05.

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