Figure 2: Network diagram of studies comparing clinical objective response (COR) of different neoadjuvant endocrine therapy (NET) therapies for HR-positive breast cancer.

Each link represents at least 1 study and the widths of each link are proportional to the number of studies comparing the particular arms. The size of each node is proportional to the total sample size. CT = chemotherapy, Ana = anastrozole, Tam = tamoxifen, Gef = gefitinib, Let = letrozole, Exe (<20wks) = Exemestane (<20wks), Exe (≥20wks) = Exemestane ((≥20wks), Cel = Celecoxib, Eve = Everolimus.