Figure 1
From: Acute blockade of IL-25 in a colitis associated colon cancer model leads to increased tumor burden
IL-25 neutralizing antibody increases tumor burden.
Balb/cJ mice were given an i.p. injection of AOM on day 0, 2% DSS in drinking water for 7 days starting on days 7 and 28 and euthanized on day 70. (A) WT Balb/c mice were given i.p. injections of either α-IL-25 or isotype control antibody on days 7, 10, 14, 21, 28, 31, 35, 42, 49, 56 and 64. (B) Body weight was monitored from initial dose of DSS and expressed as percentage of initial weight. (C) Length of colon at euthanasia. (D) Colon was removed, cut lengthwise, washed with PBS and digitally photographed. (E) Tumor counts based on gross analysis. Results are presented as mean ± SEM and are combined from four independent experiments with 3–5 mice per group. **P < 0.005.
