Figure 4: Protein function dynamics in obese patients. | Scientific Reports

Figure 4: Protein function dynamics in obese patients.

From: Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks

Figure 4

(A–C) Clustering of the functional categories altered in the age (A), T2DM (B) and gender (C) comparisons. A colour scale was used to represent up-regulated categories in red and down-regulated in blue. A detailed version of clustered categories is displayed in Supplementary Tables S7, S8, S9, respectively. (D–F) Alteration of representative cluster categories in the age (D), T2DM (E) and gender (F) comparisons. The cumulative frequency of changes (Zq) for the least redundant category in each of the clusters highlighted is represented together with a theoretical curve showing a normal distribution of data and the experimental curve representing Zq for the whole set of proteins quantified.

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