Table 1 Representative enriched categories with some of their DAP components.
p value | UniProt | Protein name | Symbol | Zq | |
|---|---|---|---|---|---|
Age comparison | |||||
Extracellular matrix (GO:0031012) | 0.00 | P14780 | Matrix metalloproteinase-9 | MMP9 | 4.25 |
Q12805 | EGF-containing fibulin-like extracellular matrix protein 1 | EFEMP1 | 3.54 | ||
P55268 | Laminin subunit beta-2 | LAMB2 | 2.90 | ||
P51888 | Prolargin | PRELP | 2.64 | ||
P02462 | Collagen alpha-1(IV) chain | COL4A1 | 2.45 | ||
P12110 | Collagen alpha-2(VI) chain | COL6A2 | 2.37 | ||
Chromatin assembly or disassembly (GO:0006333) | 0.00 | P16401 | Histone H1.5 | HIST1H1B | −2.16 |
P62805 | Histone H4 | HIST1H4A | −2.69 | ||
Q02539 | Histone H1.1 | HIST1H1A | −3.04 | ||
Mitochondrial part (GO:0044429) | 0.04 | Q8NC60 | Nitric oxide-associated protein 1 | NOA1 | −2.20 |
P06241 | Tyrosine-protein kinase Fyn | FYN | −2.21 | ||
P24310 | Cytochrome c oxidase subunit 7A1, mitochondrial | COX7A1 | −2.22 | ||
Q9NS69 | Mitochondrial import receptor subunit TOM22 homolog | TOMM22 | −2.27 | ||
P51970 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | NDUFA8 | −2.28 | ||
P53007 | Tricarboxylate transport protein, mitochondrial | SLC25A1 | −2.42 | ||
T2DM comparison | |||||
Calcium ion binding (GO:0005509) | 0.00 | P06702 | Protein S100-A9 | S100A9 | 3.61 |
P07996 | Thrombospondin-1 | THBS1 | 3.25 | ||
P05109 | Protein S100-A8 | S100A8 | 3.05 | ||
P55083 | Microfibril-associated glycoprotein 4 | MFAP4 | 2.81 | ||
P13796 | Plastin-2 | LCP1 | 2.06 | ||
P06703 | Protein S100-A6 | S100A6 | 2.02 | ||
Mitochondrion (GO:0005739) | 0.00 | P99999 | Cytochrome c | CYCS | −2.01 |
O75964 | ATP synthase subunit g, mitochondrial | ATP5L | −2.02 | ||
P50213 | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | IDH3A | −2.04 | ||
O75947 | ATP synthase subunit d, mitochondrial | ATP5H | −2.11 | ||
Q5VTU8 | ATP synthase subunit epsilon-like protein, mitochondrial | ATP5EP2 | −2.12 | ||
O75390 | Citrate synthase, mitochondrial | CS | −2.27 | ||
Q02252 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial | ALDH6A1 | −2.27 | ||
P05091 | Aldehyde dehydrogenase, mitochondrial | ALDH2 | −2.29 | ||
Q5VT66 | Mitochondrial amidoxime-reducing component 1 | MARC1 | −2.43 | ||
P38117 | Electron transfer flavoprotein subunit beta | ETFB | −2.44 | ||
Gender comparison | |||||
Inflammatory response (GO:0006954) | 0.00 | P02763 | Alpha-1-acid glycoprotein 1 | ORM1 | 5.44 |
P04003 | C4b-binding protein alpha chain | C4BPA | 3.67 | ||
P05155 | Plasma protease C1 inhibitor | SERPING1 | 3.15 | ||
P10909 | Clusterin | CLU | 2.73 | ||
P02751 | Fibronectin | FN1 | 2.42 | ||
Oxidation reduction (GO:0055114) | 0.01 | P49327 | Fatty acid synthase | FASN | 5.59 |
Q53TN4 | Cytochrome b reductase 1 | CYBRD1 | 4.35 | ||
P00450 | Ceruloplasmin | CP | 4.21 | ||
P07203 | Glutathione peroxidase 1 | GPX1 | 2.94 | ||
O75891 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | ALDH1L1 | 2.69 | ||
P22352 | Glutathione peroxidase 3 | GPX3 | 2.03 | ||
Oxidation reduction (GO:0055114) | 0.00 | P40939 | Trifunctional enzyme subunit alpha, mitochondrial | HADHA | −2.03 |
Q13162 | Peroxiredoxin-4 | PRDX4 | −2.73 | ||
P00441 | Superoxide dismutase [Cu-Zn] | SOD1 | −2.81 | ||
P00352 | Retinal dehydrogenase 1 | ALDH1A1 | −3.08 | ||
P07195 | L-lactate dehydrogenase B chain | LDHB | −3.09 | ||
P21397 | Amine oxidase [flavin-containing] A | MAOA | −3.16 | ||
P08294 | Extracellular superoxide dismutase [Cu-Zn] | SOD3 | −3.74 | ||
Q92781 | 11-cis retinol dehydrogenase | RDH5 | −6.65 | ||
Glutathione transferase activity (GO:0004364) | 0.00 | P09211 | Glutathione S-transferase P | GSTP1 | −2.35 |
P28161 | Glutathione S-transferase Mu 2 | GSTM2 | −2.55 | ||
P30711 | Glutathione S-transferase theta-1 | GSTT1 | −3.49 | ||
P09488 | Glutathione S-transferase Mu 1 | GSTM1 | −5.63 | ||
