Figure 1

Allergic airway responses are suppressed in AQP3^−/− mice.

(a) Cell population analyses in BALF by differential cell counts from WT and AQP3^−/− mice (n = 5 for each control group and n = 8 for each OVA-challenged group) on day 28. (b,c) Lung histology. Lungs of WT (n = 5 for each group) and AQP3^−/− (n = 4 for each group) mice were dissected on day 28 and stained with hematoxylin and eosin (b) or periodic acid-Schiff (c). Bars, 50 μm. The magnified figure shows the cells in the peribronchial lesion in OVA-challenged WT mice. Arrow indicates eosinophil. Bars of the magnified figure, 10 μm. (d) Serum levels of OVA-specific IgE. Serum concentrations of OVA-specific IgE were measured in WT (n = 5 for each group) and AQP3^−/− (n = 5 for each group) mice on day 21 and day 28. (e) Measurements of concentrations of IL-4, IL-13, IL-17F and IFN-γ in BALF collected on day 28 (n = 5 for each control group; n = 8 for each OVA-challenged group). **P < 0.01, *P < 0.05.