Figure 6: Efficacy of CPM against hRSV in the mouse BALB/c host model of infection. | Scientific Reports

Figure 6: Efficacy of CPM against hRSV in the mouse BALB/c host model of infection.

From: Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication

Figure 6

Animals were inoculated intranasally with hRSV Long strain. CPM and BMS-4337714 were administered intraperitoneally and by oral gavage, respectively, as a 4-day b.i.d. regimen in which the first dose was given 1 h before virus inoculation. Treatment cohorts are shown on the abscissa; animals of the infection control group were inoculated with virus and treated with vehicle only. The infectious hRSV lung titers are shown on the ordinate as log10 TCID50 per gram of lung. Each data point represents the hRSV titer for each individual animal of the respective treatment cohort. The horizontal line, drawn in each cohort, marks the geometric mean hRSV titer of the group, with the corresponding viral titer ± SD stated above. The horizontal hatched line, across the graph, represents the hRSV titer at the limit of assay detection. N = 6 mice per group.

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