Figure 4: Developmental maturation of the myelin transcriptome.
From: The transcriptome of mouse central nervous system myelin
(A) PCA plot showing transcriptome dynamics of myelin at four different ages (postnatal day 18 (P18), P75, 6 months and 24 months). (B) Venn diagram comparing all myelin mRNAs at specified ages (normalized read count; threshold >100 reads). (C) Volcano plot displaying transcripts with abundance change in myelin >2-fold between P18 and P75. X-axis displays log2-fold change between P18 and P75, and y-axis shows respective adjusted p-value as -log10. Red dots: transcripts that display fold-change abundance of at least 2-fold (203 increasing; 158 decreasing), green dots: other significantly changing transcripts, black dots: transcripts without significant change in abundance. (D) Same as in Fig. 4C showing mRNAs of which the abundance in myelin changes over 2-fold between P75 and 6 months of age. (E) Same as Fig. 4C showing mRNAs of which the abundance in myelin changes over 2-fold between 6 and 24 months of age. (F) Heat map of all mRNAs of which the abundance in myelin changes over 2-fold in any of the analyzed subsequent ages. (G) Venn diagram comparing the transcripts in myelin that are among the top 1000 most abundant at any of the analyzed ages (n = 1342) revealing 695 mRNAs among the top 1000 at all ages. (H) Heat map showing relative abundance of the combined top 1000 most abundant transcripts in myelin at any analyzed age (n = 1342 as in Fig. 3G). (I) Heat map of transcripts that were among the top 1000 most abundant mRNAs in myelin at all four analyzed ages (n = 695, subset of Fig. 3H, as in Fig. 3G). (J) Heat map of transcripts that were among the top 1000 mRNAs in myelin at only one of the analyzed ages (n = 240, subset of Fig. 3H). (K) Heat map of transcripts among the top 1000 at any two ages (n = 241, subset of Fig. 3H). (L) Heat map of transcripts among the top 1000 at any three ages (n = 166, subset of Fig. 3H). (M) Venn diagram comparing combined top 1000 myelin transcripts at any age (n = 1342 as in Fig. 3G) with the top 1000 transcripts cortex and cerebellum.
