Figure 4: Sanger sequencing and protein conservation analysis of VPS16 and SIGLEC1 variants. | Scientific Reports

Figure 4: Sanger sequencing and protein conservation analysis of VPS16 and SIGLEC1 variants.

From: Homozygous mutation of VPS16 gene is responsible for an autosomal recessive adolescent-onset primary dystonia

Figure 4

(a) Sequencing chromatograms are shown. Affected codons are framed in black, and variants found in individuals are indicated by arrows. (b) Protein alignment of VPS16 and SIGLEC1 variants from seven different vertebrate species using ClustalW. Altered Amino acid are indicated on the top panel, whereas Refseq residues are framed in red and indicated by arrows.

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