Figure 6 | Scientific Reports

Figure 6

From: Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis

Figure 6

Homologous route parenteral BCG-prime–subunit-nApa-boost regimen induces a distinct magnitude and quality of specific serum antibody response compared to the mucosal regimen.

(a,b) Serum IgG-subclass antibody responses of the i.n.–i.n. and s.c.–s.c. regimen vaccinated mice described in Fig. 5a using ELISA. The nApa- (a) and WCL-specific (b) serum IgG1, IgG2a and IgG2b levels are plotted in comparison with the corresponding non-boosted controls. Error bars at 1:100, 1:200 and 1:400 serum dilutions are means ± s.d (n = 4 mice/group). *P < 0.05; **P < 0.01 and ***P < 0.001 using the ANOVA and Bonferroni correction. s.c., subcutaneous; i.n., intranasal; vac, vaccine; WCL, whole cell lysate of Mtb.

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