Table 2 Synergism between B2088 and other antibiotics against 3 different K. pneumoniae strains.

From: Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria

Strains

Fractional Inhibitory Concentration Index with

Tobramycin

Gentamicin

Gatifloxacin

Chloramphenicol

K. pneumonia 4299

0.25

0.37

0.56

0.38

(0.125,0.125)

(0.125,0.25)

(0.06,0.5)

(0.13,0.25)

K. pneumonia 07955

0.75

0.75

0.63

0.38

(0.5,0.25)

(0.25,0.5)

(0.13,0.5)

(0.13,0.25)

K. pneumonia 31158

0.25

0.31

0.56

0.63

(0.125,0.125)

(0.25,0.06)

(0.06,0.5)

(0.5,0.13)

  1. Combinations that gave the best synergism (FICI = ≤ 0.5) are shown in bold. †The numbers in parenthesis indicate the fractional inhibitory concentration of B2088 and antibiotics used for FICI calculations.
Back to article page