Figure 5: SOD2-dependent production of H2O2 increases migration and invasion of SACC. | Scientific Reports

Figure 5: SOD2-dependent production of H2O2 increases migration and invasion of SACC.

From: SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma

Figure 5

To confirm that H2O2 production induces migration and invasion of SACC, SACC-83 cells were treated with H2O2 for 24 h. The migration and invasion of SACC-83 cells were significantly higher after treatment with 25 μM H2O2 once every 6 h (A,B). Adding H2O2 increased the protein concentrations of Vimentin, Slug, Snail, ERK, p-ERK, and MMP-2 and decreased E-cadherin protein concentrations and had no affection on expression of SOD2 (C).

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