Figure 6: Midline cross-over and axonal decussation in Polμ−/− retinas.
From: Increased neuronal death and disturbed axonal growth in the Polμ-deficient mouse embryonic retina
(a,b) Midline cross-over in WT and Polμ−/− animals was visualized at E13.5 using anterograde staining with DiI, from the retina towards the diencephalon midline (ML). The asterisk marks the position of the optic nerve head. Representative image of one of the 8 embryos analysed for each genotype. (c,d) Optic fibre decussation in WT and Polμ−/− animals was visualized at E18.5 using retrograde staining with DiI, from the lateral geniculate nucleus towards the retina. (e) The proportion of fibres that reached the primary visual fields was quantified. Histogram shows values corresponding to individual mice, together with the mean ± s.e.m. *P < 0.05 vs. corresponding controls.
