Table 1 Echocardiography data from porcine MI study.

From: Catheter-based Intramyocardial Injection of FGF1 or NRG1-loaded MPs Improves Cardiac Function in a Preclinical Model of Ischemia-Reperfusion

 

Baseline

Implant

Sacrificed

P

FS

 Control-MPs

38.4 (4.4)

19.5 (3.2)***

19.1 (2.1)

0.51

 NRG1-MPs

36.8 (4.1)

20.6 (3.2)***

27.9 (6.1)

0.025

 FGF1-MPs

40.1 (2.8)

18.8 (4.2)***

28.2 (6.1)

0.001

EDD

 Control-MPs

4.60 (0.73)

5.21 (0.71)

5.31 (0.62)

0.71

 NRG1-MPs

4.54 (0.75)

5.12 (0.56)

4.84 (0.58)

0.52

 FGF1-MPs

4.09 (0.45)

4.85 (0.73)

4.72 (0.77)

0.61

ESD

 Control-MPs

2.75 (0.71)

3.97 (0.88)

4.05 (0.78)

0.80

 NRG1-MPs

3.07 (0.59)

4.04 (0.46)**

3.91 (0.34)

0.66

 FGF1-MPs

2.48 (4.09)

4.09 (0.72)**

3.29 (0.55)

0.058

  1. Pre-implant measurements were taken 7 days after ischemia-reperfusion injury and pre-euthanasia measurements 3 months after injection. Data are means (SD). **P < 0.01 baseline versus pre-implant, ***P < 0.001 baseline versus implant; EDD: end diastolic diameter, ESD: end systolic diameter, FGF1, acidic fibroblast growth factor, FS: fractional shortening, MPs: microparticles, NRG1: neuregulin.