Figure 1: The correlation between CLU genetic variants and Aβ accumulation on AV45.

(A) Heatmap of correlation between CLU genetic variants and Aβ accumulation on AV45. The statistical relations (FDR-corrected P values) between Aβ accumulation on AV45 (rows) and CLU loci (columns) (B) rs11136000 was associated with the level of summary SUVR at baseline. The X-axis represents three genotypes while the Y-axis represents the summary AV45 retention at baseline. (C) rs1532278 was associated with the level of summary SUVR at baseline. The X-axis represents three genotypes while the Y-axis represents the summary AV45 retention at baseline. (D) rs2279590 was associated with the level of summary SUVR at baseline. The X-axis represents three genotypes while the Y-axis represents the summary AV45 retention at baseline. (E) rs7982 was associated with the level of summary SUVR at baseline. The X-axis represents three genotypes while the Y-axis represents the summary AV45 retention at baseline. (F) rs9331888 was associated with the level of summary SUVR at baseline. The X-axis represents three genotypes while the Y-axis represents the summary AV45 retention at baseline. (G) rs2279590 was associated with the level of cingulate SUVR at baseline. The X-axis represents three genotypes while the Y-axis represents the cingulate AV45 retention at baseline. (H) rs2279590 was associated with the level of frontal cortex SUVR at baseline. The X-axis represents three genotypes while the Y-axis represents the frontal AV45 retention at baseline. (I) rs7982 was associated with the level of frontal cortex SUVR at baseline. The X-axis represents three genotypes while the Y-axis represents the frontal AV45 retention at baseline. Note: SUVR, standard uptake value ratios; AV45, amyloid tracer.