Table 1 The characteristics of included seven SNPs.

From: Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

SNP

Position

Minor allele

MAF

H-W (p value)

Previous studied articles (PMID)

All

AD

MCI

NC

All

AD

MCI

NC

rs2279590

intron variant

T

0.379

0.365

0.375

0.39

0.221

0.638

0.534

0.444

[22015308], [20599866], [19734903], [21300948], [20697030]

rs11136000

intron variant

T

0.395

0.344

0.391

0.411

0.140

0.500

0.524

0.254

[21460841], [25189118], [25496871], [19734903] [20697030], [24806679], [24670887], [24117116], [23892938], [23650005], [23643458], [22722634], [22015308], [19734902]

rs9331888

intron variant, nc transcript variant, upstream variant

G

0.275

0.362

0.274

0.263

0.966

0.350

0.330

0.073

[22258514], [22122982], [20599866], [21892414]

rs7012010

nc transcript variant

C

0.306

0.271

0.318

0.292

0.945

0.932

0.381

0.437

[20697030], [19734902]

rs9331949

nc transcript variant, utr variant 3 prime

G

0.027

0.021

0.018

0.043

0.210

1.000

1.000

0.165

[23411014]

rs7982

nc transcript variant, synonymous codon

A

0.385

0.344

0.383

0.395

0.043

0.500

0.229

0.191

[20697030], [19734902]

rs1532278

intron variant

T

0.375

0.344

0.373

0.384

0.151

0.500

0.385

0.467

[21460841], [24806679]

  1. Abbreviations: SNP, single nucleotidepolymorphism; MAF, minor allele frequency; AD, Alzheimer’s disease; MCI, mild cognitive impairment; NC, normal control.
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