Table 3 Genotype frequencies of rs2736100 T > G SNP in the TERT-CLPTM1L locus among cases and controls and their association with PTC risk.

From: Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma

Studies

rs2736100 T > G

Genotypes

Cases No. (%)

Controls No. (%)

OR 2 (95% CI)

P -value

  

n = 500

n = 500

  

Zhejiang set

TT

133(26.6)

176(35.2)

Reference

 

TG

240(48.0)

235(47.0)

1.34(1.01–1.79)

0.047

GG

127(25.4)

89(17.8)

1.36(1.14–1.62)

7.4 × 10−4

  

n = 1000

n = 1000

  

Jiangsu set

TT

293(29.3)

398(39.8)

Reference

 

TG

476(47.6)

448(44.8)

1.44(1.18–1.76)

0.003

GG

231(23.1)

154(15.4)

1.43(1.26–1.62)

3.8 × 10−6

  

n = 800

n = 800

  

Jilin set

TT

218(27.3)

301(37.6)

Reference

 

TG

377(47.1)

373(46.6)

1.05(0.82–1.34)

0.695

GG

205(25.6)

126(15.8)

1.18(1.02–1.37)

0.025

  

n = 2300

n = 2300

  

Pooled

TT

644(28.0)

875(38.0)

Reference

 

TG

1093(47.5)

1056(45.9)

1.41(1.23–1.60)

4.9 × 10−6

GG

563(24.5)

369(16.0)

1.44(1.33–1.56)

8.5 × 10−8

  1. Note: PTC, papillary thyroid carcinoma; OR, odds ratio; CI, confidence interval.
  2. 1Data were calculated by logistic regression with adjustment for age and sex.
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