Figure 8 | Scientific Reports

Figure 8

From: Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death

Figure 8

Schematic diagram showing the proposed mechanisms for the synergistic chemopreventive effects of CUR and BBR on human breast cancer cells.

CUR and BBR in combination induces caspase-dependent apoptosis in breast cancer cells through ERK activation. Meanwhile, combination of these two compounds causes JNK activation, phosphorylation of Bcl-2 and dissociation of the Beclin1/Bcl-2 complex, leading to autophagic cell death in breast cancer cells.

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