Figure 3: The TRPV1 stimulation leads to STAT3 activation in GFAP+ NSCs in sensory CVOs and in GFAP+ astrocytes in thermoregulatory hypothalamic subregions. | Scientific Reports

Figure 3: The TRPV1 stimulation leads to STAT3 activation in GFAP+ NSCs in sensory CVOs and in GFAP+ astrocytes in thermoregulatory hypothalamic subregions.

From: TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation

Figure 3

Mice received an icv administration of RTX at a dose of 500 ng/kg and were sacrificed for immunohistochemistry. The central administration of RTX strongly induced the nuclear translocation of STAT3 in sensory CVOs such as the OVLT, SFO, and AP, and thermoregulatory hypothalamic subregions such as the MnPO and POA in Trpv1+/+ mice (a). Double labeling immunohistochemistry revealed the presence of STAT3+ nuclei in GFAP+ NSCs in sensory CVOs and GFAP+ astrocytes in thermoregulatory hypothalamic brain subregions (b). The nuclear translocation of STAT3 was not observed in Trpv1−/− mice (c). ac, anterior commissure; CC, central canal; 3V, 3rd ventricle; Sol, solitary nucleus. Scale bars = 50 (a, top panels of b,c) and 10 (bottom panels of b) μm.

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