Figure 4: A quantitative analysis showed that the number of STAT3+ GFAP+ cells in Trpv1+/+ mice was significantly increased in sensory CVOs and hypothalamic thermoregulatory subregions after the brain administration of 500 ng/kg RTX. | Scientific Reports

Figure 4: A quantitative analysis showed that the number of STAT3+ GFAP+ cells in Trpv1+/+ mice was significantly increased in sensory CVOs and hypothalamic thermoregulatory subregions after the brain administration of 500 ng/kg RTX.

From: TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation

Figure 4

On the other hand, the brain administration of 500 ng/kg RTX did not elevate their number in Trpv1−/− mice. The number of STAT3+ HuC/D+ neurons was also increased in Trpv1+/+ mice, but was markedly lower than that in GFAP+ cells. Data were expressed as the mean (±s.e.m.) number of STAT3+ cells per 1 mm2. *P < 0.05, **P < 0.01, ***P < 0.001 vs the vehicle in Trpv1+/+ mice or ###P < 0.001 between Trpv1+/+ and Trpv1−/− mice by ANOVA with Turkey’s post hoc tests or the Student’s t-test (n = 4).

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