Figure 5: Courses of abdominal temperatures after the administration of the TRPV1 agonist RTX or antagonist capsazepine under normal and LPS-induced inflammatory conditions. | Scientific Reports

Figure 5: Courses of abdominal temperatures after the administration of the TRPV1 agonist RTX or antagonist capsazepine under normal and LPS-induced inflammatory conditions.

From: TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation

Figure 5

Body temperature was measured with a G2 E-mitter transponder implanted intraperitoneally. (a) The brain administration of 125 ~ 500 ng/kg RTX transiently decreased abdominal core temperature in a dose-dependent manner under normal conditions. RTX reduced body temperature at doses of 250 and 500 ng/kg in Trpv1+/+ mice, but not in Trpv1−/− mice. (b) LPS-induced hyperthermia was augmented when 100 μg/kg capsazepine was infused into the brain 30 min after the administration of 100 μg/kg LPS. In contrast, RTX-induced hypothermia was facilitated by the administration of 100 μg/kg LPS, whereas LPS alone caused hyperthermia. *P < 0.05, by ANOVA with the Student’s t-test. Please refer to detailed changes in body temperature and statistical analyses (Supplemental Table).

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