Figure 8

Enhanced expression of IL-1β in the intestine of AhRR-deficient mice.

(a) colonic cultures of naïve WT and AhRR^E/E or (b) in mice fed for 6 days with 5% DSS were analyzed for expression of IL-1β (n = 6) Data are shown as mean ± s.d. and significance was determined by students t-test *p < 0.05 (AhRR^E/E vs WT). (c) pro-il-1β was assessed by qPCR in BMMΦ of WT, AhRR^E/+ and AhRR^E/E mice (n = 9–12). Data are shown as mean ± s.e.m. and significance was determined by one way ANOVA corrected for multiple comparisons by the Sidak method *p < 0.05 **p < 0.01 (AhRR^E/E vs WT or AhRR^E/E vs AhRR^E/+). (d) IL-1β production in supernatants of BMMΦ of WT, AhRR^E/+ and AhRR^E/E mice (n = 6). Data are shown as mean ± s.e.m.