Figure 6 | Scientific Reports

Figure 6

From: The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer

Figure 6

Hypothesis model of how H19 contributes to cisplatin resistance in ovarian cancer cells.

Nrf2 is degrated by Keap1 in drug sensitive cells and stabled by H19 in drug resistant cells. “Nrf2-targeted” genes which involved in GSH metabolism transcription and GSH increase in cisplatin resistant cells. High GSH causes cisplatin inactivation by GSTP1 and reduces free radicals, resulting in cisplatin resistance.

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