Figure 3: Substrate scope for decarboxylative couplings of N-Bis(Boc)-Glu(OPht)-OMe (1b) with olefins (2).
From: Visible-light photoredox synthesis of unnatural chiral α-amino acids
*Reaction conditions: under vacuum and irradiation of visible light, N-Bis(Boc)-Glu(OPht)-OMe (1b) (0.10 mmol using ketones or esters as the partners; 0.15 mmol using amides as the partners), olefin (2) (0.15 mmol for ketones and esters; 0.10 mmol for amides), [Ru(bpy)3]Cl2 (1.0 μmol), diisopropylethylamine (DIPEA) (0.25 mmol), Hantzsch ester (HE) (0.15 mmol), DCM (1.0 mL), temperature (rt, ~25 °C), time (1–5 h) in a sealed Schlenk tube. †Isolated yield.
