Figure 5
From: Reduced tonic inhibition after stroke promotes motor performance and epileptic seizures
Stroke facilitates the onset of PTZ induced seizures.
(A) Time to onset of epileptic seizures was reduced 7 days after MCAO. This effect was antagonized by gaboxadol (THIP), specifically activating extrasynaptic δ-GABAARs. THIP had no effect in control mice. Bars represent the mean ± s.e.m. [control (n = 6), control + THIP (n = 6), MCAO (n = 11), MCAO + THIP (n = 10), *p ≤ 0.05, **p ≤ 0.01]. (B) Time to onset of epileptic seizures was also reduced in GABRD+/− mice compared to their wild-type littermates (GABRD+/+). Bars represent the mean ± s.e.m. [GABRD+/+ (n = 4), GABRD+/− (n = 9), *p ≤ 0.05].
