Table 2 Multivariable regression analyses of associations of adipokines and HOMA-IR with thyroid hormones and TSH.

From: Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

 

FT4

FT3

TSH

β (95% CI)

p

β (95% CI)

p

β (95% CI)

p

Control

 Adiponectin

0. 746 (0.489, 1.004)

<0.001

−0.014 (−0.238, 0.209)

0.899

−0.026 (−0.108, 0.056)

0.540

 Resistin

1.320 (0.861,1.780)

<0.001

0.060 (−0.338, 0.459)

0.766

−0.018 (−0.164, 0.129)

0.813

 Leptin

−0.337 (−0.882 0.208)

0.225

−0.663 (−1.111, −0.215)

0.004

1.134 (1.018, 1.250)

<0.001

 HOMA-IR

−0.009 (−0.279, 0.260)

0.947

0.047 (−0.177, 0.270)

0.682

−0.036 (−0.118, 0.046)

0.386

Hypothyroid

 Adiponectin

0.732 (0.399, 1.065)

<0.001

−0.009 (−0.243, 0.225)

0.940

0.060 (−0.007, 0.128)

0.080

 Resistin

−1.064 (−1.586, −0.542)

<0.001

0.239 (−0.125, 0.602)

0.197

0.004 (−0.103, 0.110)

0.948

 Leptin

−0.555 (−1.165, 0.056)

0.075

0.025 (−0.381, 0.432)

0.902

0.631 (0.557, 0.705)

<0.001

 HOMA-IR

0.104 (−0.277, 0.485)

0. 590

0.352 (0.104, 0.600)

0.006

0.005 (−0.067, 0.078)

0.882

Hyperthyroid

 Adiponectin

0.148 (−0.006, 0.303)

0.060

0.117 (0.020, 0.214)

0.018

−0.009 (−0.036, 0.018)

0.502

 Resistin

0.903 (0.679, 1.128)

<0.001

0.408 (0.257, 0.558)

<0.001

−0.081 (−0.123, −0.038)

<0.001

 Leptin

−0.236 (0.459, −0.014)

0.038

−0.161 (−0.300, −0.021)

0.025

0.172 (0.204, 0.602)

<0.001

 HOMA-IR

−0.036 (−0.165, 0.094)

0.588

0.027 (−0.054, 0.109)

0.511

−0.011 (−0.033, 0.011)

0.326

  1. Multivariable regression analyses were conducted with age, gender, BMI, TC, TG, HDLC and LDLC as independent variables. Analyses were conducted in control, hypothyroid and hyperthyroid group separately.
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