Figure 1: Sirt6 fl/flMx1Cre mice exhibited a high bone mass phenotype.
From: Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation
(a) Microcomputed tomography (μCT) analysis of the femurs of 16-week-old Sirt6fl/fl(n = 5) and Sirt6fl/flMx1Cre (n = 5) male mice. BV/TV, bone volume per tissue volume; Tb.N, trabecular number; BMD, bone mineral density; Tb.Th, trabecular thickness. Scale bar, 1 mm. **P < 0.01. (b) Histological analysis of the femurs from 16-week-old Sirt6fl/fland Sirt6fl/flMx1Cre mice. Histology sections were stained with hematoxylin and eosin (upper) and TRAP (middle). Magnified images of the boxed area are shown (bottom). Scale bar, 50 μm. (c) Quantitative histological analysis of parameters in Sirt6fl/fland Sirt6fl/flMx1Cre mice (n = 5); N.Oc/BS, osteoclast number per bone surface; N.Ob/BS, osteoblast per bone surface. (a,c) *P < 0.01, **P < 0.05. n.s: not significant. Data are represented as mean ± S.D.
