Figure 2: Three network-search algorithms were implemented on the PseudomonasNet web server. | Scientific Reports

Figure 2: Three network-search algorithms were implemented on the PseudomonasNet web server.

From: Network-assisted investigation of virulence and antibiotic-resistance systems in Pseudomonas aeruginosa

Figure 2

(A) The pathway-centric search prioritises candidate genes for a pathway or trait by connectivity to the user-provided seed genes. (B) The gene-centric search prioritises candidate functional terms (e.g., Gene Ontology biological process terms) for a query gene based on the enrichment of known functional terms among its neighbours. (C) The context-centric search prioritises candidate genes for a context (e.g., a clinical condition, such as a drug response) as represented by differential expressed genes (DEGs). The statistical association between the neighbours of a hub gene and the DEGs are measured by a one-tail Fisher’s exact test.

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