Figure 8: NRG4 overexpression reduced chronic inflammation in obese mice.

At the end of the 3-week. after gene transfer, obese animals were sacrificed. (a) Images of EWAT stained with H&E; (b–d) Relative mRNA levels of macrophage marker genes in EWAT, liver, and BAT including F4/80, Cd68, Cd11b, Cd11c and inflammatory factor Mcp1 and Tnfα. *P < 0.05, **P < 0.01 compared to control animals (n = 5).